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Additional resources for Advanced Therapy of Prostate Disease
These incidence rates must be interpreted with extreme caution, and any conclusions drawn from them may be suspect. TABLE 3–2. ,21 1971a 1964–1966 *African = African standard population; World = World standard population. Age-Standardized Rate per 100,000 16 / Advanced Therapy of Prostate Disease The comparison of age-adjusted prostate cancer incidence rates standardized to the World Standard reveals a sharp contrast in incidence rates between black Africans and black Americans. 6 per 100,000 for white Americans.
Mol Endocrinol 1991;5:1396–404. 39. Irvine RA, Yu MC, Ross RK, Coetzee GA. The CAG and GGC microsatellites of the androgen receptor gene are in linkage disequilibrium in men with prostate cancer. Cancer Res 1995;55:1937–40. 40. Ross RK, Pike MC, Coetzee GA, et al. Androgen metabolism and prostate cancer: establishing a model of genetic susceptibility. Cancer Res 1998;58:4497–504. 41. Miller GJ. Vitamin D and prostate cancer: biologic interactions and clinical potentials. Cancer Metastasis Rev 1999;17:353–60.
32 It was concluded, therefore, that variation in the expression of 5 α-reductase could help to explain at least some of the international differences that have been observed in prostate cancer incidence. 37 Such allelic differences could provide direct mechanisms through which levels of DHT would be modulated among individuals of different genetic backgrounds. Androgen Receptors In addition to differences in circulating androgen levels, racial differences in androgen receptors (ARs) have also been detected.