Download Advances in Cancer Research, Vol. 15 by George Klein, Sidney Weinhouse, Alexander Haddow (Eds.) PDF

By George Klein, Sidney Weinhouse, Alexander Haddow (Eds.)

ISBN-10: 0120066157

ISBN-13: 9780120066155

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Experiments carried out in the authors’ laboratory, as well as by others, indicate that spontaneously oncogenic cells or normal cells that are treated with typsin do not immunize hamsters against a challenge of SV40 tumor cells. Furthermore, if the normal cell antigen were to act as TSTA, then animals should be tolerant to it unless the antigen is masked during both embryonic and adult life (which is unlikely), and SV40 would not be able to immunize hamsters against a challenge of SV40 tumor cells.

S. TEVETHIA, AND J . L. , 1967). Previous investigations had established that fixation of the transformed state in the infected cell required only one cell generation (Todaro and Green, 1966b) and that treatment of the cells a t the time of infection with interferon would prevent transformation (Todaro and Baron, 1965). The use of synchronized cell cultures revealed that if the cells were not synthesizing DNA, transformation remained interferon-sensitive, but if the cells were rapidly synthesizing cellular DNA (S phase), transformation readily became interferon-resistant (Todaro and Green, 1967).

The revertant cells appeared to be resistant to retransformation by RSV. Nevertheless, it appeared that, in this particular system, reversion was due to a loss of viral genes. A temperature-sensitive ( t s ) mutant (TI) isolated from the SchmidtRuppin strain of RSV (SR-RSV-A) has provided a good model for study (G. S. Martin, 1970). Cells transformed a t the permissive temperature by the mutant virus and then shifted to the elevated, nonpermissive temperature rapidly ( 2 4 hours) reverted back to a nontransformed phenotype.

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