By Alan S. Curry
This number of 9 essays through major experts considers the appliance of the main lately constructed analytical strategies and gear to specific poisons and medicine. It describes using HPLC, fluorescence research, and radioimmunoassays in toxicology and indicates tools particular to forensic medication.
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Extra info for Analytical Methods in Human Toxicology: Part 2
J. High Res. Chromo and ChromoComm . 2,11-14 . Gifford , 1. A. (1978) . In Reid, E. ). Blood Drugs and Other Analytical Challenges, Vol. 7. Methodological Surveys in Biochemistry . Ellis Horwood, Chichester, 61-7. , and Johnson, E. 1. J. ChromoSci. 15,413-23. Grob, K. (1978) . In Reid, E. ). Blood Drugs and Other Analytical Challenges, Vol. 7, Methodologi cal Surveys in Biochemistry . Ellis Horwood , Chichester, 89-96 . Halloran , J. , and Parker , C. W. (1966) . J. Immunol. 96,379 . A Review ofAnalytical Methods 33 Halpern , B.
Recently, a third technique has been described (Pettersson and Schill, 1981) involving the use of ion pair HPLC. With this technique an optically active pairing ion is added to the mobile pair so that a reversible complex is formed with the solute ions. The availability of separation systems capable of discriminating between enantiomers should aid a better understanding of the toxicology of enantiomers. Many drugs currently on the market are sold as racemates and it is important to consider both isomers, particularly as individual patients may show different toxicology and efficacy .
Specimens for analysis are provided by an outside laboratory. This enables the laboratory manager to compare the performance of his own laboratory with that of others carrying out the same assay. 6 CONCLUSIONS There is no single analytical technique which is universally applicable. Careful selection of technique has therefore to be made for each new assay situation. Although very few novel techniques are emerging, major advances in methodology are regularly being achieved by adaptions of existing systems.